A Phi Beta Kappa and cum laude graduate of Brown University and Harvard Law School respectively, Gale began her professional career as a health care attorney, working for 7 years as staff counsel for Stanford University and 11 years as Vice President for Legal Services at California Pacific Medical Center. She left the law in 1994 and became actively involved with various community organizations.

A long-time board member of the Jewish Community Center of San Francisco, Gale served as the Center's board president and then as co-chair of the capital campaign to construct the JCC's new facility. She is a co-founder and former board chair of Gateway High School, an award winning public charter high school. She has also been a board member of the Jewish Community Federation of San Francisco, the Contemporary Jewish Museum, and the San Francisco Jewish Film Festival.

Gale's development experience includes working as the Director of Development for Gateway High School and as Director of Major Gifts for Huckleberry Youth Programs. More recently, she was the Chief Program Officer at the Koret Foundation.